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ChaC1, which is referred to as Botch in the report [113], is induced and promotes neurogenesis by antagonizing Notch signaling in mouse models

Mar 2017;274(3):1245-1250

In line with that, Superoxide dismutase 1 ( Sod1) knockout mice and mice expressing mutated Sod1 exhibit increased PC in sciatic nerve and skeletal muscle, respectively ( Gpx4 haploinsufficient mice fed a high fat-high sucrose diet exhibit increased 4-HNE adducts in liver and heart ( The second line of defense involves direct detoxification of free RLAs by specialized phase I and II metabolic enzymes ( +/ NAD(P)H cofactors to oxidize RLAs to their corresponding acids or reduce them to alcohol

Doussiere J, Gaillard J, Vignais PV