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Commonly reported issues include mild gastrointestinal discomfort, particularly when starting the compound, and temporary headaches during the adjustment period
Lifespan extension with preservation of hippocampal function in aged system x (c)()-deficient male mice

Intriguingly, in addition to its therapeutic effect on rodent motor neurons, Cu (II)-atsm treatment may also improve astrocyte function in patients with SOD1 mutations (Dennys et al., 2023), which is significant as glia reprogrammed from fibroblasts of patients with SOD1 mutations have been shown to induce hyperexcitability and cell death in healthy control motor neurons (Di Giorgio et al., 2008

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