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Covalent binding of acetyl group to liver proteins were observed after treating rats with 14 C-acetyl-labeled AcINH but not with aromatic ring 14 C labeled AcINH, indicating that AcHz is responsible for INH hepatotoxicity in rats13, 16

This method can be extended to high-throughput analysis of various seed morphological traits, significantly accelerating breeding programs aimed at cultivar improvement [75]

doi: 10.1016/j.cca.2019.01.021

For example, while polyphenol-based treatments may significantly reduce inflammatory cytokines in animal models, equivalent clinical trials may show only marginal improvements in human subjects [126,127,128]