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Description
Variants are pathway-level: they don't predict response to any specific compound, but they describe the metabolic and longevity terrain a clinician is prescribing into
Together, they create sustained elevation of growth hormone that mimics the natural patterns the body produces during youth
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Under continuous weekly exposure the receptor desensitizes: semaglutide is a full beta-arrestin recruiter (GLP-1R Emax 106%, Coskun 2022 Table S2
