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Patient phenotype critically defines the responsive subset

After quality control, we identified 47,413 cases of CAD (31,127 in men, 16,286 in women), 7961 cases of ischemic stroke (4915 in men, 3046 in women), 12,926 cases of heart failure (8456 in men, 4470 in women), and 18,382 cases of AF (12,260 in men, 6122 in women)

Fat Metabolism and Weight Management L-Carnitine helps the body use fat as a primary energy source

Progesterone's metabolite allopregnanolone acts on the same GABA-A receptors targeted by benzodiazepines when progesterone falls in perimenopause, this endogenous calming signal weakens, leaving the nervous system structurally less buffered against stress