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The 2025 Prohibited List and WADAs explanatory note on the modifications can be found here

Studies have shown that enhancing insulin sensitivity through supplementation with insulin-sensitizing additives such as chromium, thiazolidinediones, or lipoic acid can improve animal performance during heat stress (Ranganathan et al., 2006

Indeed, studies have shown that glucagon receptor-knockout (GCGR-KO) mice exhibit resistance to streptozotocin-induced type 1 diabetes and high-fat diet (HFD)-induced type 2 diabetes 5,6,7

However, aggregate data and covariates of interest (eg, sex, disease severity) are not consistently reported across randomised clinical trials (RCTs).6 The use of individual patient data (IPD) has several advantages, such as it allows for the exploration of the relationship between treatment effects and patient-level characteristics, and it overcomes restrictions in using the information reported in the publication among others