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The N, N-Di(2-hydroxybenzyl) ethylenediamine-N, N-diacetic acid monohydrochloride (HBED), an iron chelator, mitigates iron-related damage by binding ferrous ions, facilitating their transport across BBB, and converting them to ferric ions

Polyunsaturated fatty acids undergo nonenzymatic peroxidation when oxygen radicals generated by mitochondrial ROS production remove a hydrogen atom from the lipid, resulting in a lipid radical that can propagate to generate more peroxyl/alkoxyl radicals and hydroperoxide [83]

Evidence suggests MRS is inadequate, however, and often yields inconsistent results across studies

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