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The intense fight or flight sensation experienced during opiate withdrawal is rooted directly in this dysregulated stress circuitry

2 Oxidative stress and periodontitis 2.1 Basic concepts of oxidative stress Oxidative stress refers to an imbalance between the production of reactive oxygen types (involving superoxide anions, hydrogen peroxide, etc.) and other oxidants in the cellular and extracellular environment, capable of damaging cell structures and functions ( Under normal conditions, the body regulates and neutralizes these parlous oxidants by antioxidant systems (including superoxide dismutase, glutathione peroxidase, etc.), remaining redox balance within cells (Menzel et al., 2021)

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Neurophotonics 3 , 041805 (2016)