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Description
An important intermediate required for the synthesis of spermidine and spermine from putrescine is derived from S -adenosylmethionine (SAM)
Lemaitre RN

This single event triggers three major downstream signaling pathways that collectively govern neuronal health: the MAPK/ERK pathway, the PI3K/Akt pathway, and the PLCgamma pathway

It was found that the combination of sulfasalazine with cisplatin improved the toxicity of cisplatin on human lung cancer cells overexpressing GSTP (Figure 9A) [191]
