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Oral administration of SFN after CCl 4 significantly decreased serum ALT in mice and reduced necrotic zones and lipid peroxidation in the liver ( 4 in mice was also ameliorated by SFN treatment, possibly through Nrf2-mediated antioxidation and enhanced acetaldehyde metabolism (Ishida et al., 2021)

Additionally, macrophages within psoriatic plaques display dysregulated iron metabolism, contributing to elevated local iron levels and increased oxidative damage

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