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Description
CGA protects rat cortical neurons against glutamate-induced neurotoxicity and oxidation [195] and prevents AMPA-induced neurotoxicity in oligodendrocytes derived from the optic nerve through suppression of PKC and caspase-dependent signaling [196]
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Research in this field demonstrates marked heterogeneity in study design, ranging from uncontrolled case series to randomized controlled trials (RCTs) of variable quality

Additional factors have been implicated in the induction of ferroptosis 13 , including the engagement of mitochondrial metabolism and the tricarboxylic acid (TCA) cycle 14,15
