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As mentioned earlier, the most important effect of incretins is to stimulate the production and secretion of insulin by the pancreas, and clinical studies show that the activation of this process, whether by stimulation of GLP-1 by semaglutide alone or simultaneous stimulation of GLP-1/GIP by tirzepatide, is associated with better glycemic control in type 2 diabetics

While some of this research was funded by Novo Nordisk (the maker of Ozempic, Wegovy, Saxenda, and Victoza), the results are clearpeople on semaglutide lost nearly twice as much weight and hit the 5-percent weight-loss milestone in half the time

Indirect antioxidants and systems level modulators such as PUFAs, folates or folinic acid, and prebiotics or probiotics also show promise

doi: 10.1530/eje.0.1390552