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The severity of colon mucosal damage was evaluated using the colonic mucosal damage index (CMDI) following the criteria outlined by 2.6 H&E and AB-PAS staining Paraffin-embedded colonic tissue blocks were cut into 4-m-thick sections for H&E staining (Table 2

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Those three human pilots include: a Phase I safety study in healthy volunteers (2003, well-tolerated)

However, not all studies have found GABAergic differences in autism (Kolodny et al., 2020), and one recent study instead found elevated glutamate in primary sensorimotor cortex, which correlated positively with parent-reported SOR (He et al., 2021)