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The trial product estimand addressed the average treatment effect in all randomly assigned participants, assuming that the drug or placebo was taken as intended (participants on treatment)
In addition, these long-term superantigens could also contribute to immune exhaustion and a state of unresponsiveness (anergy) on the part of T lymphocytes due to chronic exposure to these antigens [307]
de Fays L, Van Malderen K, De Smet K, Sawchik J, Verlinden V, Hamdani J, et al
Resistance Development of drug resistance is a key element in the failure of chemotherapy treatment
