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GSEA was performed utilizing the Kyoto Encyclopedia of Genes and Genomes (KEGG) database for pathway enrichment analysis 33 , with Benjamini-Hochberg adjustment for multiple testing

and Type V, although less common, is characterized by fat distribution predominantly in the calves Notably, some literature also describes involvement of the lower abdomen, especially in Types I and II, although this is not consistently reflected across all classification systems.8,15,21,22 Regarding morphological appearance, lipedema progresses through four clinical stages (Table 2): Stage I is characterized by smooth skin with thickened but soft subcutaneous tissue containing small nodules

When they work together, they create an antioxidant synergy that is far stronger than any one nutrient alone

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