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I used a hypothetical example to demonstrate these mutations impact on the detoxification process

A key mechanism for GSHs role in DNA synthesis relates to maintenance of reduced glutaredoxin or thioredoxin, which are required for the activity of ribonucleotide reductase, the rate-limiting enzyme in DNA synthesis [30]

Moreover, pterostilbene is capable to palliate negative health effects caused by mitochondrial mutations and to activate SIRT3 as well as its mitochondrial deacetylase function [411]

In Vitro Cell.Dev.Biol.-Plant 59 , 227248 (2023)
