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Tumor necrosis factor-alpha inhibits growth factor-mediated cell proliferation through SHP-1 activation in endothelial cells

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74 Chronic overnutrition, a sedentary lifestyle and IR in adipose tissue can directly lead to the production and accumulation of excess toxic lipid products (such as diacylglycerol, ceramides, and NEFAs), and the metabolites can aggravate the ectopic lipid deposition through some signaling pathways (such as mTOR and notch)

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