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Biocrates platforms have the potential of to classify AD, PD, MS, and systemic conditions by applying multivariate metabolic signatures obtained from easily accessible biofluids, including plasma and tears

However, a later study found that, in fact, a very negligible amount of radiolabelled 125 I-bGH gets transported to the mitochondria compared to other subcellular compartments, including microsomes, endosomes, lysosomes, and Golgi bodies [20], suggesting that GH does not act directly on mitochondria

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Succinate drives the production of IL1, mediated by HIF1 (39) whereas citrate accumulation leads to the production of itaconate, a potent inhibitor of isocitrate lyase, which is necessary for Mtb persistence (43)