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[7] [8] Weight regain typically follows discontinuation, and concerns persist regarding disproportionate lean mass loss during rapid reduction, potentially exacerbating sarcopenia in vulnerable populations, as empirical data highlight the need for combined lifestyle interventions to preserve muscle

doi: 10.1016/S0308-8146(01)00289-8

Shih et al., 2015

The destructive potential of chemotherapeutic drugs delivered to the brain tumor is also considered