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The different hGSTP1-1 mutants show slightly altered regioselectivities in the formation of the individual GSH conjugates of clozapine which suggests that the binding orientation of the reactive nitrenium ion of clozapine is affected by the mutations [34]

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Similarly, the addition of 1 mM GABA led to a -31.76% decrease in stem Na content

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However, modern nutraceutical science has overcome this hurdle through the development of sustained-release (SR) formulations

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