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Description
The absence of evidence in this case is not an accident
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Furthermore, having already knowledge on natural history and validated tools for outcome assessment, placebo-controlled trials can be designed in a way that conclusions are provided much faster and with less insecurity, enabling all patients to undergo treatment quickly [259]
If the rate of metabolic heat production exceeds the rate of total heat loss (e.g., non-steady-state exercise, extremely hot and humid environmental conditions), the rate of heat storage is positive and deep body temperature rises
