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1 Introduction Lipid peroxidation is a complex process in which oxidants attack lipids-containing carbon-carbon double bonds, leading to oxidative degradation of lipids, formation of lipid peroxides, and subsequent cellular condition change ( + T cells in PD-L1 blockade therapy induced increased lipid peroxidation in tumor cells and contributed to the antitumor efficacy of immunotherapy ( 2 An overview of lipid peroxidation Lipid peroxidation is a metabolic process that involves the oxidative degradation of lipids and consists of three stages: initiation, propagation, and termination ( Figure 1 )

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