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503 Despite these advances, the use of first- and second-generation mTOR inhibitors has been associated with a range of side effects such as insulin resistance, hyperglycemia, impaired wound healing, hypertension, and various metabolic, renal, and pulmonary complications

J., Vander Kooi C

Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency

The inclusion or not inclusion of NAC for all patients in the protocols reduces the bias of selection by the characteristics of the patients and can be evaluated as an effect added to standard treatment at this moment
