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Laboratory studies demonstrate that FOXO4-DRI effectiveness depends on senescent cell burden, tissue type, and the specific mechanisms maintaining senescent cell viability in different experimental conditions
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29,37 Norrin protein can also bind to Frizzled class receptor 4 (FZD4) and LRP5/6 to form a ternary complex and promote the downstream signal transmission of Wnt/-catenin
Interestingly, increased GSTP1 expression has been shown to maintain the CSC phenotype in lung adenocarcinoma and facilitated metastasis through regulating EMT (Wang et al
