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As NRF2 transcriptional activity diminishes with age, the cells ability to mount an appropriate defense against baseline non-radical ROS such as H 2 O 2 , is compromised [8]

Another possibility is that there is an association of this SNP with another disease that is highly correlated with depression

[PubMed] [Google Scholar] 98.Mahakalkar S.M., Nagrale D., Gaur S., Urade C., Murhar B., Turankar A

The underlying mechanism responsible for the reversal of mitochondria-dependent apoptosis induced by H 2 O 2 , consequent to elimination of intracellular Ca 2+ was explored by employing 2-aminoethyl diphenylborinate (2-APB), a commonly used inositol 1,4,5-trisphosphate receptor(IP3R) inhibitor [17]