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The most common early symptoms included orthostatic hypotension (62%), urinary issues (52%), and difficulty walking (45%)
doi: 10.1677/erc.1.01222
doi: 10.1194/jlr.R048975
AP1 is a complex of several proteins including JUN, which is upregulated in motor neurons derived from SOD1 patients compared to other neurons, providing potential mechanistic insights into the selective degeneration of motor neurons in ALS (Bhinge et al., 2005)
