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& Wargo, J

Discovery of RG7388, a potent and selective p53-MDM2 inhibitor in clinical development
doi: 10.1046/j.1526-4637.2003.03005.x

In liver ischemiareperfusion injury, propofol (1 mgkg 1 ) effectively inhibited mitochondrial oxidative stress, reducing liver damage by mitigating hypoxia-inducible factor 1 alpha (HIF-1)-driven mitochondrial dysfunctions and cell apoptosis [22]
