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Secondary carnitine deficiencies are most commonly the result of trapping of carnitine in fatty acylcarnitine due to defects in mitochondrial fatty acid -oxidation enzymes such as is the case in medium-chain acyl-CoA dehydrogenase deficiency (MCADD)

However, the present study is the first prospective clinical trial in which the beneficial effects of L-carnitine supplementation on physical and mental functional abilities in patients with cirrhosis and chronic fatigue were assessed through the use of a self-report questionnaire

Epinephrine was added to the assay mixture, containing tissue supernatant, and the change in extinction coefficient was followed at 480 nm in a spectrophotometer

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