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These are the findings: In old patients with ACL rupture, surgery is not recommended due to the persons low level of activity and knee osteoarthritis
Humanized preclinical models of BDNF regulation and genetic variability, such as iPSC-derived neurons and brain organoids support the evaluation of BDNF regulation in a patient-specific manner, aligned with efforts developing personalized interventions [328]
Furthermore, SLC25A51 deficiency markedly decreased the phosphorylation levels of AKT, mTOR, and S6K, which was counteracted by proline replenishment [194,199]
