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Upper body subcutaneous and visceral adipose tissues are the most important contributors to circulating NEFA reaching the liver (58, 59), and while the visceral adipose tissue mass is much smaller, it drains directly into the portal vein, potentially explaining the strong correlation between visceral fat and liver triglycerides (60, 61), a relationship also observed in lean individuals (62)

published in-vitro findings on hTERT upregulation in human somatic fibroblast cell cultures

The TDP-43 aggregate sequesters microRNAs and proteins such as mitochondrial proteins encoded by the nuclear genome resulting in dysregulation of mitochondria and amplified oxidative stress

A 2017 meta-analysis reinforced these findings