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Description
Ebeling PR, Jones JD, OFallon WM, Janes CH, Riggs BL

Metformin-related vitamin B12 deficiency may cause or accelerate distal symmetrical and autonomic neuropathy in the patient with diabetes (35)

Signs of B-12 deficiency can include fatigue, weakness, sore tongue, nerve pains, insomnia, depression, canker sores, easy bruising, numbness and tingling in hands or feet, and memory problems
Its not only about effectivenesscomfort matters too
