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Significant gene-sets were selected by control of the false discovery rate, FDR at 25% 75

[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed

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It is usually described as persistent metallic, sour, bitter or other unusual or bad taste in the mouth