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Moreover, microbial metabolites such as short-chain fatty acids and secondary bile acids influence thyroid hormone metabolism by regulating hepatic deiodinase activity, enterohepatic circulation, and tissue sensitivity to T 3 (Miquel et al., 2013
Najaf Amin et al
75 All these studies defined frailty according to Fried et al, who describe a physical frailty phenotype consisting of the presence of three or more of the following characteristics: unintentional weight loss, weakness, exhaustion, low physical activity, and slowness in motor performance
This study has several limitations