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Liang C, Dobson AJ, Chung HF, Van Der Schouw YT, Sandin S, Weiderpass E et al (2024) Association of infertility and recurrent pregnancy loss with the risk of dementia

Knockout studies of DNA methyltransferases ( DNMT1 or DNMT3A/DNMT3L ) result in impaired spermatogenesis and infertility, underscoring the importance of methylation in gametogenesis and embryonic development [177, 178]
Since mutant ChaC1-knock-in mice have been examined only in limited situations, it remains ambiguous whether a deficiency of CHAC 1 activity affects phenotypic properties under pathological conditions such as ER stress, oxidative stress, and ferroptosis
