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Conflict of interest: ZW, BSL, and SLH are named as co-inventors on pending and issued patents held by the Cleveland Clinic relating to cardiovascular diagnostics and therapeutics, and have the right to receive royalty payment for inventions or discoveries related to cardiovascular diagnostics or therapeutics from Cleveland HeartLab, Quest Diagnostics, and Procter & Gamble

In another study, oral choline was administered to several omnivores and vegans without a healthy history of previous illnesses after 2 months, TMAO levels were significantly elevated by blood tests (Zhu et al., 2017), revealing a link between dietary red meat intake and the pathogenesis of atherosclerosis (Figure 3)

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