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39 Based on a physiologically-based pharmacokinetic [PBPK] model in healthy adults, ~88% of CP1 total clearance was attributed to hepatic elimination with the remaining clearance ascribed to renal elimination

However, the cyanocobalamin form of B-12 does not occur in nature normally, but is a byproduct of the fact that other forms of B-12 are avid binders of cyanide (-CN) which they pick up in the process of activated charcoal purification of the vitamin after it is made by bacteria in the commercial process

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How COMT Connects To The Rest Of Your Super Seven Methylation is upstream of COMT