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Men with hypogonadism may experience low libido, fatigue, reduced muscle mass, and infertility, while women may face irregular periods, hot flashes, and trouble conceiving

J Med Chem 64:99069915 Ericson MD, Freeman KT, Lavoi TM, Donow HM, Santos RG, Giulianotti MA, Pinilla C, Houghten RA, Haskell-Luevano C (2023) The parallel structure-activity relationship screening of three compounds identifies the common agonist pharmacophore of pyrrolidine bis-cyclic guanidine melanocortin-3 receptor (Mc3r) small-molecule ligands

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