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2 Materials and methods 2.1 Study design This study was a multi-center, prospective, double-blind, randomized clinical trial aimed to assess the absorption rate and hence bioavailibility of an innovative oral Sucrosomial B12 (Sidevit B12 developed by Pharmanutra S.p.A, Pisa, Italy) in enhancing circulatory B12 levels in healthy deficient adults, compared to various conventional oral B12 supplement formulations, selected randomly from local pharmacies at each participating center

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SAM, another substrate of NNMT, not only provides methyl groups for histone and DNA methylation but also provides propylamine groups for polyamine biosynthesis