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Given that OCM-1 cells possess a higher density of folate targeting receptors compared to ARPE-19 cells 33,34 , MCNs/Ln/GD/FR NPs conjugated with FA are expected to more effectively target OCM-1 cells than ARPE-19 cells under identical conditions (Supplementary Fig

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Also, pericytes in the BBB differ from pericytes in the body in their numbers, that is, there is a large number of pericytes located in the CNS compared to other body tissues, thereby making the ratio of pericytes to endothelial cells in the CNS higher (1:1 to 1:3) compared to other cells, such as the muscles (1:100)

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