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Results from the PIVENS trial showed that oral administration of the anti-oxidant vitamin E improved liver dysfunction and the pathological conditions of NASH [17]
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Nrf2 is kept in the cytosol by Keap1 under non-stressful conditions and undergoes proteosomal degradation (Kensler et al, 2007)
as a pheromone (277) , it is interesting to note that this may also involve crosstalk of ERG (37) , due in part to the complex networks in which it may be embedded (278)
Some solid cancers also exhibited high level of GPX4 expression including melanoma, gastric, endometrial, prostate and colorectal cancers
