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for benign tumors and for malignant neoplasms with and without metastasis

In venous thrombosis models, FXII and FXI contribute to thrombus formation, which is correlated with elevated levels of citrullinated histone H3 (146)

Although the specific mechanism is not completely clear at present, from the perspective of its important regulatory role on GABAergic neurons, the abnormality of ARX may affect the normal development and function of GABAergic neurons, leading to the imbalance of brain neural circuits, thus causing ASD related symptoms ( Dysfunction of GABAergic interneurons has been observed in animal models of ASD

4,5 Sensitisation, in turn, is associated with increased responsiveness of neural activity following a given stimulus