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The OAZ2 gene is located on chromosome 15q22.31 and is composed of 5 exons that generate two alternatively spliced mRNAs that encode two distinct protein isoforms

As we age, cartilage diminishes as it gets attacked by antibodies (age-related degradation of joint cartilage)

Thyroid hormones exhibit profound metabolic effects characterized by an increased rate of both catabolic and anabolic reactions, resulting in an overall acceleration of the basal metabolism which is associated with increased oxygen consumption, respiratory rate, energy expenditure, and heat production (56)

Additionally, the treatment was effective in upregulating heme oxygenase-1 (HO-1) due to the activation of ERK and Akt signaling pathways [114]