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FIGURE 4 2.21 Clinical trial insights into Alzheimers disease research Clinical trials form the cornerstone of translational research, bridging the gap between preclinical findings and practical therapeutic applications

The decreased virulence of the sod1 strain may be due to increased susceptibility to oxygen radicals within macrophages, while other antioxidant defense systems in can compensate for the loss of Cu-Zn SOD in vivo [76]

The mitochondria are the primary intracellular site of oxygen consumption and, despite the presence of a wide array of antioxidants and detoxifying enzymes, are the major source of reactive oxygen species (ROS), most of them originating from the mitochondrial respiratory chain

4, 124133 10.1038/ncb744 [DOI] [PubMed] [Google Scholar] 110.Yoshino, A., Setty, S.R.G., Poynton, C., Whiteman, E.L., Saint-Pol, A., Burd, C.G.et al
