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Major modifications for 2026 As outlined in the 2026 Summary of Major Modifications and Explanatory Notes, the major modifications for 2026 include the following: Further examples or clarifications have been added to the following substance classes to help athletes and their entourage better identify prohibited substances: S1

Insulin-like growth factor 1 (IGF-1): a growth hormone

An improperly reconstituted compound introduces variables that can compromise an entire study

(Some formulas are compatible with sperm, oocytes, and embryos and are therefore meant for people who are trying to conceive.) And although lube can be helpful for addressing vaginal dryness, some people find that a vaginal moisturizer is better suited to that purpose