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Description
LDHB KD significantly downregulated GSH synthesis genes, such as glutamate-cysteine ligase (GCL) catalytic and modifier subunits (GCLC and GCLM), GSH synthetase (GSS), and GSH reductase (GSR), as well as the GSH gene signature ( Figure 1f
The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases

Acyl-CoA synthetase long-chain family member 4, a key enzyme in phospholipid metabolism, facilitates the conversion of PUFAs, such as arachidonoyl and adrenic acid, into PUFA-CoA (25)

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