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Simultaneous KD of NRF2 and LDHB further reduced SLC7A11 and the downstream GCLC and primed sensitivity to the ferroptosis inducer RSL3 ( Figure 6g, h )
A-485 is a selective catalytic inhibitor of p300 that blocks histone acetylation and lactylation in preclinical models, leading to impaired cancer cell proliferation and metastasis 184
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Scheres, S
