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Deregulated intracellular pathways define novel molecular targets for HBV-specific CD8 T cell reconstitution in chronic hepatitis B

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Finally, Progressive fibrosis leads to cirrhosis, which subsequently promotes portal hypertension and liver failure, which is the main reason for liver-related mortality in NAFLD ( 4 Exosome in NAFLD 4.1 Role of exosomes in NAFLD pathophysiology 4.1.1 Exosomes in the pathogenesis of NAFLD Several recent studies point to a significant role of Extracellular Vesicles (EVs) in the pathophysiology and progression of NAFLD and NASH