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Conditions like Alzheimers or diabetes involve ROS , but antioxidants alone cant cure them

Control and p21 KO cells pretreated with Gem also conserved a larger portion of the existing (m+0) intracellular GSH pool after treatment with erastin2 compared with cells pretreated with DMSO, with weaker effects observed in p53 KO cells (Fig 4G)

Another in vitro study showed that LA pretreatment (100 M) for 48 h could significantly attenuate acrolein-induced degeneration in IMR-90 human pulmonary fibroblasts by increasing cell viability, mitochondrial function, intracellular ATP levels and antioxidation capacity [194]

doi: 10.1186/s40364-023-00487-4 12 ZhaoEHouJCuiH