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Stable-Isotope Dimethyl Labeling Stable-isotope dimethyl labeling employs different isotopomers of formaldehyde and cyanoborohydride to introduce dimethyl groups to the N-termini and side chains of lysine residues which differ by at least 4 Da
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In aged AD model mice, tau is overexpressed, the cerebral microvessels are disrupted, and abnormal malformed vascular masses form, and cortical atrophy occurs (234)
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