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carried out a limit test to determine the acute oral toxicity and the lethal dose 50 (LD 50 ) and some genotoxicity tests of the polyphenolic compound contained in a marc extract (titled at 74.8% in procyanidins) in rats

[DOI] [PubMed] [Google Scholar] Natsch A., Schmid J., Flachsmann F

doi: 10.1016/j.eclinm.2023.101995 [DOI] [PMC free article] [PubMed] [Google Scholar] 174.Kang S, Brinker A, Jones SC, et al

Preservation of Neurovascular Unit Integrity The integrity of the blood brain barrier (BBB) and neurovascular units (NVU) cellular function is essential for CNS homeostasis via the regulation of influx/efflux transport and neurovascular coupling, ensuring adequate cerebral perfusion, while providing a protective barrier against potentially harmful molecules in the peripheral circulation [225]